Publication: Endoglin -CD105- immuno expression in human foetal and neonatal lungs
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Date
2008
Authors
Barresi, Valeria ; Grosso, Maddalena ; Vitarelli, Enrica ; Granese, Roberta ; Barresi, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Endoglin is a 180 KDa glycoprotein mainly
expressed on endothelial cells of newly formed vessels.
Its expression is increased by the hypoxia inducible
factor 1 (HIF-1), a potent stimulator of VEGF
expression. The relative hypoxic environment in which
foetal lung develops favours HIF-1 dependent gene
expression, including the endoglin and VEGF ones.
Herein, we analysed endoglin immunoexpression in the
human neonatal and foetal lung throughout gestation.
Lungs from 18 foetuses (9-41 weeks), 7 preterm and 2
term infants were submitted to the immunohistochemical
study. A slight immunostaining was found in some
mesenchymal aggregates in the lungs of foetuses at the
first trimester of pregnancy. At mid gestation, endoglin
was evidenced in peri-tubular mesenchymal stem cells
or in peri-canalicular vessels and in the endothelia of
peri-bronchial vessels; by contrast, no immunoreaction
was observed in case of Down syndrome or in a foetus
with cardiac malformations. At late gestation and in
preterm infants, endoglin antibody labelled endothelia of
the alveolar capillaries and of peri-bronchial vessels. In
case of alveolar capillary dysplasia (ACD) or
macrosomy associated with maternal diabetes, endoglin expression was restricted to peri-bronchial vessels; no
immunoreaction was encountered in foetuses with IUGR
(intra-uterine growth restriction) or massive pulmonary
haemorrhage. Lungs of term infants both displayed
atelectasis; there was no evidence of endoglin
immunoexpression in one case, whereby only the
endothelia of peri-bronchial vessels were stained in the
other. Our study suggests that lung vasculogenesis
endures throughout gestation. Absence of endoglin
staining in some pathologic conditions may reflect lung
vasculogenesis disorders; nonetheless, since each
pathologic state is represented by a single case in our
cohort, further studies are required to clarify this issue.
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