Publication: The Grueneberg ganglion, a novel sensory system in the nose
Authors
Fleischer, Joerg ; Breer, Heinz
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Within the nasal epithelium of mammals,
there are several compartments which are populated with
neuronal cells. One of them – the so-called Grueneberg
ganglion – is composed of ciliated neurons residing in
the anterior region of the nose. Although cells of the
Grueneberg ganglion lack direct contact with the lumen
of the nasal cavity, they are endowed with features
indicative of olfactory sensory neurons, such as the
olfactory marker protein and distinct olfactory receptors,
as well as projection of axonal processes to the olfactory
bulb of the brain. These findings have led to the notion
that the Grueneberg ganglion might be a novel olfactory
subsystem; a concept which was lately supported by the
observation that chemical cues activate Grueneberg
ganglion neurons. Unexpectedly, it was recently found
that these cells also respond to cool ambient
temperatures, presumably via a signaling pathway
mediated by second messengers. Thus, the Grueneberg
ganglion may operate as a dual sensory organ involved
in the detection of both chemical and thermal stimuli.
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Citation
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