Publication: Rhinophyma - unusual expression of simple-type keratins and S1 00A in sebocytes and abundance of VIP receptor-positive dermal cells
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Date
1996
Authors
Wollina, U.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Rhinophyma represents a severe variant of
rosacea, a common mid-facial erythematous dermatosis.
Increased blood flow and pooling in skin are thought to
be involved in its pathogenesis. Since neuropeptides and
their receptors are responsible for local blood flow
regulation, immunolocalization for the vasoactive
intestinal peptide (V1P)-receptor(R) was performed in
slice biopsies taken from five patients with glandular
rhinophyma. Additional immunostainings included
intermediate filaments (keratin, vimentin) and neuroglandular
antigen (NGA). In contrast to controls,
rhinophyma disclosed not only a more dense distribution
of VIP-R positive cells within the endothelium but
immunoreactive perivascular large cells. The immature
sebocytes stained positive with monoclonal antibody
Cam5.2 against glandular antigens and polyclonal anti-
S100A. Elastotic connective tissue in the dermis showed
a strong immunoreactivity for vimentin and NGA. From
these results we suggest that, (a) ligands of the VIP-R
may contribute to vascular and dermal alterations in
rosacea and (b) immature sebocytes show an unusual
antigen expression of SlOOA and glandular keratin.
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