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Traumatic brain injury: Estimate of the age of the injury based on neuroinflammation, endothelial activation markers and adhesion molecules

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dc.contributor.authordell'Aquila, Massimiliano
dc.contributor.authorMaiese, Aniello
dc.contributor.authorDe Matteis, Alessandra
dc.contributor.authorViola, Rocco Valerio
dc.contributor.authorArcangeli, Mauro
dc.contributor.authorLa Russa, Raffaele
dc.contributor.authorFineschi, Vittorio
dc.date.accessioned2023-01-24T08:51:30Z
dc.date.available2023-01-24T08:51:30Z
dc.date.issued2021
dc.description.abstractStudies on traumatic brain injury (TBI) are applicable not only in the clinical context, but also in the forensic field. Over time, the literature has accumulated scientific evidence supporting the use of specific histopathological tests in dating traumatic brain injuries. In primary damage, cell death occurs by necrosis/apoptosis. In secondary injury, the underlying mechanisms are inflammation and ischemia. The inflammatory response of the central nervous system (CNS) follows the common steps of the innate response. In head injury, the blood brain barrier (BBB) undergoes both functional damage and, subsequently, finer structural changes. Scientific evidence has shown modifications of the junctional-endothelial system that favors the extravasation of immunocompetent cells. The histological evaluation of the subdural hematoma, of the cerebral contusions, of the diffuse axonal damage can certainly bring useful elements, with limitations, to the chronological evaluation of the lesions. Many markers have been used to better define the dating of the head injury. Several authors also analyzed the usefulness of secondary damage markers in brain tissue. The progress achieved with immunohistochemistry is significant compared to the use of routine staining. With immunohistochemistry it is possible to identify much narrower and more precise time intervals and, above all, with greater probative reliability. Recently attention has been paid to the modification of structural proteins and miRNAs. Future research is already started and entrusted to multidisciplinary teams that know how to combine their specific skills in search of a reproducible standard of known and sufficient accuracyes
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dc.format.extent12es
dc.identifier.citationHistology and Histopathology Vol. 36, nº8 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-319
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/127723
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectTraumatic brain injuryes
dc.subjectAge estimationes
dc.subjectImmunohistochemistryes
dc.subjectBraines
dc.subjectPathologyes
dc.subjectForensic sciencees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleTraumatic brain injury: Estimate of the age of the injury based on neuroinflammation, endothelial activation markers and adhesion moleculeses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36, nº8 (2021)