Publication: Flavonoids’ effects on Caenorhabditis elegans’ longevity, fat accumulation, stress resistance and gene modulation involve mTOR, SKN-1 and DAF-16
Authors
Guerrero Rubio, María Alejandra ; Hernández García, Samanta ; Gandía Herrero, Fernando ; García Carmona, Francisco
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Publisher
MDPI
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DOI
https://doi.org/10.3390/antiox10030438
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info:eu-repo/semantics/article
Description
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This manuscript version is made available under the CC-BY 4.0
license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Antioxidants. To access the final edited and published work see https://doi.org/10.3390/antiox10030438
Abstract
Flavonoids are potential nutraceutical compounds present in diary food. They are considered health-promoting compounds and promising drugs for different diseases, such as neurological and inflammatory diseases, diabetes and cancer. Therefore, toxicological and mechanistic studies
should be done to assert the biological effects and identify the molecular targets of these compounds. In this work we describe the effects of six structurally-related flavonoids—baicalein, chrysin, scutellarein, 6-hydroxyflavone, 6,7-dihydroxyflavone and 7,8-dihydroxyflavone—on Caenorhabditis elegans’lifespan and stress resistance. The results showed that chrysin, 6-hydroxyflavone and baicalein prolonged C. elegans’ lifespan by up to 8.5%, 11.8% and 18.6%, respectively. The lifespan extensions
caused by these flavonoids are dependent on different signaling pathways. The results suggested that chrysin’s effects are dependent on the insulin signaling pathway via DAF-16/FOXO. Baicalein and 6-hydroxyflavone’s effects are dependent on the SKN-1/Nfr2 pathway. In addition, microarray
analysis showed that baicalein downregulates important age-related genes, such as mTOR and PARP.
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Citation
Antioxidants 2021, 10, 438.
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