Publication: The signaling network of tumor invasion
Authors
Wang, G.K. ; Zhang, W.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The ability of a cell to invade its
surroundings is an important hallmark of malignant
tumors and results from aberrant cell signaling
mechanisms. The signal transduction that leads to tumor
invasion can be broken down into major pathways. Even
though the pathway systems are distinct in themselves,
none of these pathways operate independently when it
comes to transmitting signals that culminate in an
invasive phenotype. That is, the malignant change in one
receptor not only leads to malignant changes directly
downstream but can also affect the molecules of many
other pathways. Three major pathway systems involved
in tumor invasion are discussed in this review: the
integrin system, the insulin-like growth factor system,
and the Rho family GTPases. Here we see that although
the individual signaling systems can each contribute to
invasion, each system is networked to others and should
not be considered isolated. Each system is first reviewed
as independent contributors to an invasive phenotype
and then discussed in the context of interacting pathways
that collectively result in tumor invasion.
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