Publication: Morphological and morphometrical study on the dorsal skin of Wistar and WBNIILA-Ht rats in their developing stage.
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Date
1998
Authors
Iwamoto, S. ; Nakayama, Hiroyuki ; Doi, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The detailed histology of the dorsal skin of
Wistar-derived hypotrichotic WBNIILA-Ht rats (HtRs)
was examined in their developing stage (at 3 and 7
weeks of age) using Wistar rats (WRs) as controls. As a
result, except for the existence of time-lag in the hair
follicular cycle and some quantitative differences, there
were no essential qualitative differences between the two
strains. The follicular epithelial cell number and the
amounts of tonofilaments and trichohyalin granules were
less in HtRs than in WRs in the same phase of hair
follicular cycle. In addition, the diameter of hair shaft
was significantly larger in WRs than in HtRs at 7 weeks
of age. The number of proliferating cell nuclear antigen
(PCNA)-positive epidermal basal cells decreased in
HtRs and increased in WRs from 3 to 7 weeks of age,
respectively. Apoptosis was sparsely observed in the
sebaceous gland epithelia1 cells, keratinizing portion of
hair cuticules and inner root sheath in both strains, but
the frequency of apoptosis in the hair follicle was
somewhat higher in 7-week-old HtRs. HtRs are
considered to be useful experimental animals for
dermatotoxicological studies.
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