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Causes of death and survival in alcoholic cirrhosis patients undergoing liver transplantation: influence of the patient’s clinical variables and transplant outcome complications

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dc.contributor.authorBolarín, J. M.
dc.contributor.authorPérez Cárceles, María Dolores
dc.contributor.authorLuna, A.
dc.contributor.authorMinguela, A.
dc.contributor.authorMuro, Manuel
dc.contributor.authorHernández del Rincón, Juan Pedro
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-11T10:50:11Z
dc.date.available2024-07-11T10:50:11Z
dc.date.issued2021-05-27
dc.description© 2021 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Diagnostics. To access the final edited and published work see https://doi.org/10.3390/diagnostics11060968
dc.description.abstractBackground. Clinical and molecular mechanisms involved in the cause and time of death of alcoholic cirrhosis (AC) patients undergoing liver transplantation (LT) are not entirely understood. In sudden death cases, judicial autopsy practice is mandatory for determining the cause and circumstances of death. The medico-legal autopsy data are essential for helping health authorities to guide future public health activities, assess the effectiveness of health systems, and adopt the necessary preventive measures to improve and adapt the treatments in order to increase these patients’ survival. Objective. Our study aimed to determine the different clinical and sociodemographic causes that influence the different causes of death and the short- and long-term survival of AC patients undergoing liver transplantation. Methods. A total of 122 deceased AC patients undergoing LT were analyzed at different times post-transplantation. The main pre- and post-transplant complications were analyzed in relation to the cause of death and the patient’s survival, as well as the causes and time at which the patient’s death occurred. Results. A total of 53.3% of non-sudden death was observed. A large number of the deaths of AC patients undergoing transplantation were due to non-sudden death, sepsis, and graft failure (GF), the main causes of death in the sample being similar in both sexes. In non-sudden deaths, there were no significant differences between the death rates either related or not related to the liver transplant. Sepsis was the main cause, with the highest percentage (21.3%) of mortality, followed by GF (18.9%) and multiorgan failure (15.6%) at ten years. Furthermore, our results showed how pre-transplant clinical complications, such as viral infections and encephalopathy, influence the age at which multiorgan failure occurs in the transplanted patient. Conclusion. Multiorgan failure is the leading cause of sudden death, with higher mortality during the first year after transplantation, followed by sepsis and GF. Our results show the vulnerability of AC patients, both in the hospital period after the transplant and outside.es
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dc.format.extent18es
dc.identifier.citationDiagnostics 2021, 11(6), 968
dc.identifier.doihttps://doi.org/10.3390/diagnostics11060968
dc.identifier.issnElectronic: 2075-4418
dc.identifier.urihttp://hdl.handle.net/10201/142991
dc.languageenges
dc.publisherMDPI
dc.relationOur work was possible thanks to supporting from Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness. Grants number PI15/01370 and P19/01194 and co-funding of the European Union with European Fund of Regional Development (FEDER) with the principle of “A manner to build Europe”.es
dc.relation.publisherversionhttps://www.mdpi.com/2075-4418/11/6/968
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAlcoholic cirrhosises
dc.subjectCauses of deathes
dc.subjectForensic medicinees
dc.subjectHuman clinical toxicologyes
dc.subjectLiver transplantes
dc.subjectMedico-legal autopsyes
dc.subjectSurvivales
dc.titleCauses of death and survival in alcoholic cirrhosis patients undergoing liver transplantation: influence of the patient’s clinical variables and transplant outcome complicationses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationb6e0add0-b2d7-4a9a-ad70-12b701f2cb29
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoveryb6e0add0-b2d7-4a9a-ad70-12b701f2cb29
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