Functional morphology of the equine pelvic flexure and its role in disease. A review

Lopes, M.A.F.; Pfeiffer, C. J.

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Functional morphology of the equine pelvic flexure and its role in disease. A review

dc.contributor.author	Lopes, M.A.F.
dc.contributor.author	Pfeiffer, C. J.
dc.date.accessioned	2020-07-23T14:32:37Z
dc.date.available	2020-07-23T14:32:37Z
dc.date.issued	2000
dc.description.abstract	The hindgut is the major site in the horse for nutrient digestion and absorption . Most of this activity occurs in the large intestinal compartments, i.e., cecum, right and left ventral colon and left and right dorsal colon. The colonic pelvic flexure is a short and narrow loop connecting the left ventral and left dorsal colon. It is not significant directly in digestive and absorptive processes but plays an important functional role in regulating colonic aboral and retropropulsive transit of digesta through its motility pacemaker activity. The pelvic flexure also contributes to the pathophysiology of colic, the leading cause of death in horses. Its narrow lumen may contribute to colonic impaction, and malfunctions of the pacemaker may contribute to volvuli and colonic displacements. Neuronal and ganglion density of the myenteric plexus is increased at the pelvic flexure and adjacent left dorsal colon pacemaker region. Contractile activity, vasoactive intestinal peptide (VIP) and neurokinins-l and -3 are all enhanced in the pelvic flexure. The mucosa histologically resembles that of the ventral and dorsal colon , with apically-granulated principal cells and goblet cells lining the luminal surface. Clustered intranuclear inclusions resembling the cytoplasmic granules are also observed by electron microscopy in the principal cells as elsewhere in the horse colon. Further neuroendocrine and morphologic investigation of the pelvic flexure is warranted due to the great importance of this localized region for normal function and pathophysiology.	es
dc.format	application/pdf	es
dc.format.extent	9	es
dc.identifier.citation	Histology and Histopathology, Vol. 15 n.º 3 (2015)
dc.identifier.issn	1699-5848
dc.identifier.issn	0213-3911
dc.identifier.uri	http://hdl.handle.net/10201/95175
dc.language	eng	es
dc.publisher	F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Horse	es
dc.subject	Colon	es
dc.subject	Motility	es
dc.subject	Pacemaker	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología	es
dc.title	Functional morphology of the equine pelvic flexure and its role in disease. A review	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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