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Antinuclear antibody-keratinocyte interactions in photosensitive cutaneous lupus erythematosus

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dc.contributor.authorFurukawa, F.es
dc.date.accessioned2011-02-22T11:09:01Z
dc.date.available2011-02-22T11:09:01Z
dc.date.issued1999
dc.description.abstractAutoimmune diseases are characterized by various circulating autoantibodies, especially antinuclear antibodies (ANA). It has been a long-standing issue as to whether andlor how ANA interact with epidermal cells to produce skin lesions. Of these ANA, the anti-SS-AIR0 antibody is the most closely associated with photosensitivity in patients with systemic lupus erythematosus (SLE) and its subgroups, including subacute cutaneous lupus erythematosus (SCLE) and neonatal lupus erythematosus (NLE). SS-A/Ro antigens are present in the nucleus and cytoplasm, and interestingly, ultraviolet B (UVB) light translocates these antigens to the surface of the cultured keratinocytes. Thus, anti-SS-AIR0 antibodies in the sera can bind to the relevant antigens expressed on the UVB-irradiated keratinocyte surface, and have been speculated to be an important inducer of antibody-dependent keratinocyte damage. This interaction between the anti-SS-A/Ro antibodies and UVBirradiated keratinocytes may induce the skin lesions through a cytotoxic mechanism. This review will focus on the involvement of antibody-dependent cellular cytotoxicity in the pathogenesis of the skin lesions observed in photosensitive cutaneous lupus erythernatosus.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19192
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectKeratinocytees
dc.subjectAutoantibodyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleAntinuclear antibody-keratinocyte interactions in photosensitive cutaneous lupus erythematosuses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.14, nº 2 (1999)