Publication:
The role of HSP40 in cancer: Recent advances

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Zhong-39-845-851-2024.pdf(389.81 KB)
Date
2024
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Authors
Zhong, Bi-xi ; Shen, Fu-ming ; Chen, Ji-kuai
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-693
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info:eu-repo/semantics/article
Description
Abstract
Heat shock proteins (HSPs) are a family of proteins involved in protein folding and maturation that are expressed by cells in response to stressors including heat shock. Recent studies have demonstrated that HSPs play major roles in carcinogenesis by regulating angiogenesis, cell proliferation, migration, invasion, metastasis, apoptosis, as well as therapy resistance to certain anticancer drugs. Despite being the largest and most diverse subgroup of the HSP family, HSP40 (DNAJ) is an understudied family of co-chaperones. HSP40 family members are also known to be involved in various types of cancers. In this article, we review the involvement of human HSP40 family members in various aspects of cancer biology. In addition, we highlight the possible potential of HSP40 as a tumor biomarker or drug target for improving the prognosis and treatment of cancer patients in the future
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HSP40 , Cancer , Diagnostic biomarker , Molecular chaperone protein , Prognosis , Target therapy
Citation
Histology and Histopathology Vol. 39, nº7 (2024)
URI
http://hdl.handle.net/10201/142168
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Histology and histopathology Vol.39, nº7 (2024)
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