Publication: Tumor-associated neoexpression of the pS2 peptide and MUC5AC mucin in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder
Loading...
Date
2008
Authors
Kunze, E. ; Krassenkova, I. ; Fayyazi, A.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
To gain more detailed insight into the
histogenesis of primary nonurachal adenocarcinomas
and signet ring cell carcinomas of the urinary bladder,
we analyzed by immunohistochemistry the expression of
a broad panel of proteins, associated with cell
differentiation (pS2 peptide, MUC5AC, MUC6,
spasmolytic polypeptide, cyclooxygenases-1 and -2,
caveolin-1), and of various novel known or candidate
tumor suppressors (14-3-3 sigma, SYK, PTEN, maspin).
Included were 12 adenocarcinomas admixed to
urothelial carcinomas, 10 pure adenocarcinomas and 5
signet ring cell carcinomas. As the most important
finding, the majority of signet ring cell carcinomas and
three quarters of the adenocarcinomas (72.7%)
expressed the pS2 peptide, and nearly half of the
adenocarcinomas (45.5%) as well as most of the signet
ring cell carcinomas were observed to secrete the
MUC5AC apomucin. Since expression of both proteins
was absent in the normal nonneoplastic urothelium, their
tumor-associated appearance is regarded as a
neoexpression or reexpression, respectively, of normally
cryptic antigenic determinants, and is assumed to be
involved in the phenotypical formation of vesical adenocarcinomas, including signet ring cell carcinomas.
The expression of both pS2 and MUC5AC in variants of
urothelial carcinomas with a glandular differentiation
and an extracellular mucus production support the
concept that adenocarcinomas may histogenetically
develop from preexistent TCC. Adenocarcinomas which
secrete the pS2 peptide and the MUC5AC glycoprotein
are proposed to be subclassified as adenocarcinomas of
the intestinal type, as distinguished from those of the
common type lacking an expression. The tumor
suppressor genes showed a loss of protein expression in
adenocarcinomas, ranging from 54.5% (14-3-3 sigma),
to 31.8 (PTEN), 27.3% (SYK) and 18.2% (maspin). Similar expression profiles in the coexistent urothelial
carcinomas argue against a specific involvement of these
genes during the morphogenesis of adenocarcinomas.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.