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Prognostic analysis of astrocytic gliomas correlating histological parameters with the proliferating cell nuclear antigen labelling index (PCNA-LI)

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dc.contributor.authorCruz-Sánchez, F. F.
dc.contributor.authorFerreres, Joan-Carles
dc.contributor.authorFigols, J.
dc.contributor.authorPalacín, A.
dc.contributor.authorCardesa, Antonio
dc.contributor.authorRossi, M.L.
dc.contributor.authorVal-Bernal, José Fernando
dc.date.accessioned2017-06-06T12:28:05Z
dc.date.available2017-06-06T12:28:05Z
dc.date.issued1997
dc.description.abstractEighty out of 250 cases of astrocytic glioma collected from a practice served by a single clinical team over a 15-year period were studied using a full complement of clinical, follow up, histopathological analysis and proliferating cell nuclear antigen (PCNA) immunostaining for the obtention of the PCNA-labelling index (LI). A statistical evaluation and discriminant analysis were carried out with the aim of clarifying the importance of various parameters as predictors of tumor behaviour. Data are correlated with survival (with a 10- year follow up). A significant correlation with survival was found when histological grouping and the PCNA-LI were studied with the Cox test. Most significant features were histological as detected using classical techniques including histological grading. The utilization of objective values (mitosis, cellular density and necrosis) appears to be useful in grading astrocytic tumors. Our results emphasize the importance of cytological, histological and PCNA-LI parameters as predictors of tumor behaviour.
dc.formatapplication/pdfes
dc.format.extent7
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/53196
dc.languageenges
dc.publisherMurcia : F. Hernández
dc.relation.ispartofHistology and histopathologyen_EN
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAstrocytomaen_EN
dc.subjectPrognosisen_EN
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
dc.titlePrognostic analysis of astrocytic gliomas correlating histological parameters with the proliferating cell nuclear antigen labelling index (PCNA-LI)en_EN
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.12, nº 1 (1997)