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Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways

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dc.contributor.authorOrlova, Valeria V.
dc.contributor.authorLiu, Zhen
dc.contributor.authorGoumans, Marie-José
dc.contributor.authorten Dijke, Peter
dc.date.accessioned2016-04-28T16:43:01Z
dc.date.available2016-04-28T16:43:01Z
dc.date.issued2011
dc.description.abstractGenetic studies in mice and humans have revealed a pivotal function for transforming growth factor-beta (TGF-β) in vascular development and maintenance of vascular homeostasis. Mice deficient for various TGF-β signaling components develop an embryonic lethality due to vascular defects. In patients, mutations in TGF-β receptors have been linked to vascular dysplasia like Hereditary Hemorrhagic Telangiectasia (HHT) and pulmonary arterial hypertension (PAH). Besides indirect effects by regulating the expression of angiogenic regulators, TGF-β also has potent direct effects on endothelial cell growth and migration, and we have proposed that TGF-β regulates the activation state of the endothelium via two opposing type I receptor/Smad pathways, activin receptor-like kinase (ALK)1 and ALK5. TGF-β is also critical for the differentiation of mural precursors into pericytes and smooth muscle cells. Furthermore, defective paracrine TGF-β signaling between endothelial and neighboring mural cells may be responsible for a leaky vessel phenotype that is characteristic of HHT. In this review, we discuss our current understanding of the TGF-β signaling pathway and its regulation of endothelial and vascular smooth muscle cell function.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/49414
dc.languageenges
dc.publisherF. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología.es
dc.relation.ispartofHistology and histopathology, Vol. 26, nº9 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAngiogenesises
dc.subjectPulmonary arterial hypertensiones
dc.subject.other61 - Medicinaes
dc.titleControlling angiogenesis by two unique TGF-β type I receptor signaling pathwayses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº9 (2011)