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Biocatalytic synthesis of panthenyl monoacyl esters in ionic liquids and deep eutectic solvents

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dc.contributor.authorÁlvarez, Elena
dc.contributor.authorBernal, Juana M.
dc.contributor.authorDonaire González, Antonio
dc.contributor.authorVilla Aroca, Rocío
dc.contributor.authorLozano Rodríguez, Pedro
dc.contributor.authorNieto Cerón, Susana
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2021-11-03T17:30:43Z
dc.date.available2021-11-03T17:30:43Z
dc.date.copyright© 2013 The Royal Society of Chemistry
dc.date.issued2019-05-21
dc.description.abstractThe enzymatic synthesis of six panthenyl monoacyl esters (PMEs) was carried out by the direct esterification of fatty acids (i.e. capric, lauric, myristic, palmitic, oleic and linoleic acids, respectively) with panthenol in different ionic liquids (ILs) based on cations with a long alkyl side-chain (e.g. 1-dodecyl-3-methylimidazolium tetrafluoroborate [C12mim][BF4], etc.). All the assayed ILs were seen to be suitable reaction media for Novozym 435-catalyzed synthesis of PMEs (i.e. up to 90% conversion and 100% selectivity), enabling easy recovery and the reuse of both biocatalyst and IL. Alternatively, mixtures of panthenol with free fatty acids were seen to act as deep eutectic solvents (DES), that were excellent reaction media for the biocatalytic synthesis of PMEs (i.e. up to 83% conversion and 98% selectivity in the case of the panthenyl monolaurate), the enzymatic activity remaining unchanged for seven consecutive cycles of reuse. The enzymatic synthesis of PMEs by direct esterification using the DES approach can be considered as a clean and useful process for the sustainable industrial scaling up of panthenyl acyl ester production.es
dc.formatapplication/pdf
dc.format.extent9es
dc.identifier.citationGreen Chemistry, 2019, Vol. 21, Issue 12, pp. 3353-3361
dc.identifier.doihttps://doi.org/10.1039/C9GC01076A
dc.identifier.issnElectronic: 1463-9262
dc.identifier.urihttp://hdl.handle.net/10201/113639
dc.languageenges
dc.publisherRoyal Society of Chemistryes
dc.relationNombre del proyecto: Nuevos procesos multi-catalíticos verdes basados en la tecnología de los líquidos iónicos: Desde las materias primas sencillas hasta los químicos con valor añadido (GreenCatILs). Código: RTI2018-098233-B-C21. Agencia/entidad financiadora: Ministerio de Ciencia e Innovación (MICINN). Ámbito Nacional. Proyectos de I+D+i «Retos investigación» correspondientes al Programa Estatal de I+D+i Orientada a los Retos de la Sociedad, en el marco del Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020. Convocatoria 2018. Nombre del proyecto: Procesos (bio)catalíticos sostenibles en líquidos iónicos y su aplicación a la industria cosmética y farmacéutica. Código: 20790/PI/18. Agencia/entidad financiadora: Fundación Séneca. Ámbito Nacional, Ayudas a la realización de proyectos para el desarrollo de investigación científica y técnica por Grupos Competitivos. Convocatoria 2017.es
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlelanding/2019/gc/c9gc01076aes
dc.rightsAttribution-NonCommercial-NoDerivates 4.0 International
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAntarctica lipase Bes
dc.subjectEsterificationes
dc.subject.otherCDU::5 - Ciencias puras y naturales::54 - Químicaes
dc.titleBiocatalytic synthesis of panthenyl monoacyl esters in ionic liquids and deep eutectic solventses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/acceptedVersión
dspace.entity.typePublicationes
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