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Retinal ischemic diseases and promising therapeutic molecular targets

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dc.contributor.authorLee, Deokho
dc.contributor.authorTomita, Yohei
dc.contributor.authorNegishi, Kazuno
dc.contributor.authorKurihara, Toshihide
dc.date.accessioned2025-01-08T09:43:25Z
dc.date.available2025-01-08T09:43:25Z
dc.date.issued2025
dc.description.abstractRetinal ischemia is a fundamental pathologic condition associated with retinal vascular occlusion, glaucoma, diabetic retinopathy, age-related macular degeneration, and other eye diseases. Extensive inflammation, redox imbalance, apoptosis, and abnormal vascular formation in retinal ischemia could lead to visual impairments. Developing or finding effective treatments is urgently needed to protect the eye against retinal ischemia and related damage. To address the demand, we have searched for promising therapeutic molecular targets in the eye (e.g., hypoxia-inducible factor [HIF], peroxisome proliferator-activated receptor-alpha [PPARĪ±], and nicotinamide adenine dinucleotide [NAD+]), and found that modulations of each molecular target might protect the eye against retinal ischemic damage in terms of complex pathologic mechanisms. In the current article, we review and update the therapeutic evidence of modulation of HIF, PPARĪ±, or NAD+ and discuss future directions for developing promising drugs based on these molecular targets. This summary urges research to obtain more solid evidence of each molecular target in retinal ischemic diseases.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and Histopathology Vol. 40, nĀŗ01 (2025)
dc.identifier.doihttps://doi.org/10.14670/HH-18-756
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/147998
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiaciĆ³n externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHypoxia inducible factores
dc.subjectNicotinamide adenine dinucleotidees
dc.subjectPeroxisome proliferator-activated receptor-alphaes
dc.subjectRetinal ischemiaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĆ­a. Medicina clĆ­nica. OncologĆ­aes
dc.titleRetinal ischemic diseases and promising therapeutic molecular targetses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nĀŗ1 (2025)