Hepcidin and dicentracin peptides show preventive antiviral applications against NNV infection in European sea bass through immunomodulatory roles

Cervera Martínez, L.; Arizcun Arizcun, M.; Mercado, L.; Chaves Pozo, E.; Cuesta Peñafiel, Alberto

Publication:
Hepcidin and dicentracin peptides show preventive antiviral applications against NNV infection in European sea bass through immunomodulatory roles

dc.contributor.author	Cervera Martínez, L.
dc.contributor.author	Arizcun Arizcun, M.
dc.contributor.author	Mercado, L.
dc.contributor.author	Chaves Pozo, E.
dc.contributor.author	Cuesta Peñafiel, Alberto
dc.contributor.department	Biología Celular e Histología
dc.date.accessioned	2024-02-14T23:11:33Z
dc.date.available	2024-02-14T23:11:33Z
dc.description	© 2024. The authors. This document is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc /4.0/ This document is the published version of a published work that appeared in final form in Aquaculture.
dc.description.abstract	Aquaculture is an extremely prosperous market threatened by pathogen outbreaks, including viruses as nodavirus (NNV), which infect fish species with special interest in trading such as European sea bass. Antimicrobial peptides (AMPs) might constitute potential antiviral agents, which had been previously evaluated in fish with positive prospects, based on their properties as immunomodulators or directly killing pathogens. In this line, we aimed to evaluate this dual role by administering two European sea bass synthetic AMPs (Hamp or Dic) prior to NNV infection. Both treatments conferred partial protection against NNV though viral replication and load were not affected. Both AMPs elicited, prior to infection, AMP response and leukocyte mobilization whilst downregulated pro-inflammatory markers. Upon infection, Hamp and Dic peptides abrogated the inflammatory response provoked by NNV as well as avoid NNV-induced disturbance of the leucocyte distribution in the brain, mainly neutrophils, macrophages and CD8+ T cells. This study points that preventive applications of synthetic Hamp and Dic peptides exert their antiviral actions through the immunomodulatory role and not by a direct action of the antimicrobial on NNV. This work opens the door to the use of AMPs as potential prophylactic tools against NNV as well as immunostimulant in fish farms
dc.format	application/pdf	es_ES
dc.identifier.citation	Aquaculture, Vol.: 583, 30 March 2024, 740592
dc.identifier.issn	0044-8486
dc.identifier.uri	http://hdl.handle.net/10201/139390
dc.language	eng	es_ES
dc.publisher	Elsevier
dc.relation.isreferencedby	ED_IDENTRADA=1352
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S004484862400053X?via%3Dihub
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S004484862400053X?via%3Dihub
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	Atribución-NoComercial 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject	Nodavirus	es_ES
dc.subject	Antimicrobial peptides (AMPs)
dc.subject	Antivirals
dc.subject	Hepcidin
dc.subject	Dicentracin
dc.subject	European sea bass
dc.subject	Aquaculture
dc.title	Hepcidin and dicentracin peptides show preventive antiviral applications against NNV infection in European sea bass through immunomodulatory roles	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dspace.entity.type	Publication	es
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