Publication:
Salivary gland carbonic anhydrases

Simple item page
dc.contributor.authorRedman Robert S.
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2025-10-27T07:28:14Z
dc.date.available2025-10-27T07:28:14Z
dc.date.issued2025
dc.description.abstractCarbonic anhydrases (CA) are zinc metalloenzymes that catalyze the reversible conversion of carbon dioxide and water to bicarbonate. For most mammalian cells, this reaction is essential to maintaining intracellular physiological pH. For salivary glands, it also has an important role in the regulation of the pH and buffering capacity of their secretory product, saliva, which is central to the activity of salivary digestive enzymes. This review is a chronological narrative of the discovery and distribution of CA and its isoenzymes in mammalian salivary glands and saliva and the role of CA in regulation of salivary pH via secretion of the salivary CA isoenzyme and the secretion and reabsorption of bicarbonate from the ductal lumen. The interaction of sodium/bicarbonate co-transporters and other factors in these processes is briefly described. The distribution of CA among mammalian species, salivary glands, and gland cells as determined by CA activity in saliva and gland extracts, enzyme histochemistry, and immunohistochemistry is presented in tables. The importance of salivary CA to oral health is underscored by the reduction in salivary gland and salivary CA activity by nutritional zinc deficiency and genetic variants of two of the CA isoenzymes, which cause dysgeusia and hyposalivation and are associated with increased dental caries
dc.formatapplication/pdf
dc.format.extent18
dc.identifier.citationHistology and Histopathology, Volúmen 40, nº11 (2025), 1675-1692
dc.identifier.doihttps://doi.org/10.14670/HH-18-917
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/169069
dc.languageeng
dc.publisherServicio de Publicaciones, Departamento de Histología e Histopatología
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBicarbonate
dc.subjectCarbonic anhydrase
dc.subjectEnzyme histochemistry
dc.subjectImmunohistochemistry
dc.subjectSaliva
dc.subjectSalivary glands
dc.subjectZinc metalloenzymes
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleSalivary gland carbonic anhydrases
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Redman-40-1675-1692-2025.pdf
Size:
4.03 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.37 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology, Vol.40, Nº11, (2025)