Publication: Primary central nervous system lymphomas in immunocompetent patients
Authors
Guinto, G. ; Félix, I. ; Aréchiga, N. ; Arteaga, V. ; Kovacs, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Primary Central nervous system lymphoma
is a rare non-Hodgkin’s tumor of the brain that has been
traditionally found in patients with immunodeficiency
syndromes. However, there are several immunocompetent
patients that have also been reported with this
neoplasm. In this group of patients, the mean age of
diagnosis is around 60-year old, with a very slight
predominance in women. Macroscopically, most of the
tumors are unique and mainly located in the
supratentorial region in the proximity of the
cerebrospinal fluid circulation. The typical histological
pattern is a perivascular distribution of tumor cells,
within a network of reticulin fibers. Even though they
are usually well defined masses, it is not rare to find
tumor invasion beyond the macroscopic margin.
Coagulative necrosis is not as common as in
immunodeficiency-related cases. Immunohistochemistry
has demonstrated that most of the tumor cells are Blymphocytes
and the electron microscopic findings do
not differ from those reported in systemic non-Hodgkin’s
lymphomas. There are several histological classifications
of these tumors, some of them with recent modifications
to facilitate the analysis, but unfortunately, up now with
a little or no clinical significance. The diagnosis is based
on the histological study of the specimen obtained
mainly through a Stereotactic biopsy. The treatment is
based on a combination of chemotherapy followed by radiotherapy, but the mortality rate is still high.
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