Publication: The distribution, immune complex trapping ability and morphology of follicular
dendritic cells in popliteal lymph nodes of aged rats
Authors
Sato, H. ; Dobashi, Michio
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Immune system function declines with age,
and lymph nodes involute. The aims of the study were to
describe the distribution of follicular dendritic cells
(FDCs) in the lymphoid follicles of aged rats, and to
determine whether these cells have reduced ability to
trap immune complexes (ICs). Popliteal lymph nodes of
rats aged 24-28 months were immunostained for S-100
protein as a marker of FDCs. Some rats were pretreated
with peroxidase-anti-peroxidase complex (PAP) as an
1C. FDCs were densely distributed in lymphoid follicles,
which contained many primary follicles and a few
secondary follicles. FDCs in primary follicles stained
weakly for S-100 protein, and showed weak trapping,
while those in secondary follicles stained strongly for
both S-100 protein and trapping. Ultrastructurally, in
involuted lymphoid follicles FDCs were atrophic. We
conclude that FDCs in aged rats are densely distributed
in involuted follicles and show reduced trapping ability
and atrophic morphology. This seems to reflect the long
life of FDCs and the reduced numbers of lymphoid cells
in these follicles. We suggest that FDCs in aged rats may
show some of their normal functions if fully developed
germinal centers are induced, and may not play an
important role in the process of involution of the
follicles.
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