Publication:
Detection of anti-mullerian hormone receptor II protein in the postnatal rat testis from birth to sexual maturity

Simple item page
dc.contributor.authorMendis-Handagama, S.M.L.C.es
dc.contributor.authorDi Clementi, N.es
dc.contributor.authorAriyaratne,H.B.S.
dc.contributor.authorMrkonjich, L.
dc.date.accessioned2011-06-30T12:02:15Z
dc.date.available2011-06-30T12:02:15Z
dc.date.issued2006
dc.description.abstractAnti-Mullerian hormone (AMH) produced by the immature Sertoli cells negatively regulates the postnatal Leydig cell (i.e. adult Leydig cells/ALC) differentiation, however, the mechanism is sparsely understood. AMH negatively regulates the steroidogenic function of fetal Leydig cells (FLC) and ALC. However, when this function is established in the ALC lineage and whether AMH has a function in FLC in the postnatal testis are not known. Therefore, the objectives of this study were to examine the presence of AMH receptor type II (AMHR-II) in FLC and cells in the ALC lineage in the postnatal mammalian testis using the rat model Male Sprague Dawley rats of days 1, 5, 7-21, 28, 40, 60 and 90 were used. AMHR-II in testicular interstitial cells was detected in testis tissue using immunocytochemistry. Findings showed that the mesenchymal and the progenitor cells of the ALC lineage, were negative for AMHR-II. The newly formed ALC were the first cell type of the ALC lineage to show positive labeling for AMHR-II, and the first detection was on postnatal day 13, although they were present in the testis from day 10. From days 13-28, labeling intensity for AMHR-II in the ALC was much weaker than those at days 40-90. FLC were also positive. The time lag between the first detection of the newly formed ALC in the testis and the first detection of AMHR-II in them suggests that the establishment of the negative regulatory role of AMH on ALC steroidogenesis does not take place immediately upon their differentiation; no change in cell size occurs during this period. The absence of AMHR-II in mesenchymal cells suggests that it is unlikely that the negative regulatory effect of AMH on ALC differentiation in the postnatal testis is achieved via a direct action of AMH on mesenchymal cells. The presence of AMHR-II in postnatal FLC suggests a possible role by AMH on FLC, which warrants future investigations.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22619
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPostnatal testises
dc.subjectLight microscopyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleDetection of anti-mullerian hormone receptor II protein in the postnatal rat testis from birth to sexual maturityes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Detection of antimullerian hormone receptor II protein in the postnatal rat testis from birth to sexual maturity.pdf
Size:
1.9 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.21, nº 2 (2006)