Publication: Electron and immunoelectron microscopy on healing process of the rat anterior cruciate ligament after partial transection: the roles of multipotent fibroblasts in the synovial tissue
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Date
1996
Authors
Maekawa, K. ; Furukawa, H. ; Kanazawa, Y. ; Hijioka, A. ; Suzuki, K. ; Fujimoto, Sunao
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The healing process of the rat anterior
cruciate ligament (ACL) after partial transection
was examined. In sham operated samples, the synovial
tissue near the infrapatellar fat pad includes an
abundance of young fibroblasts which can be classified
into two types: A type cells often exist along the
surface of the synovial tissue and contain numerous
lysosomes, while B type cells are often associated
with small vessels and are actively involved in the
production of fibronectin and laminin. At 1 week
after transection of the ACL, B type cells frequently
undergo mitotic proliferations and are eventually
incorporated into the endothelium of the growing
capillaries extending from the proximal remnants of
the synovial tissue to the transected lesion. The
transformation of B to A type cells is indicated by our
electron micrographs. After 2 weeks, the replacement
of the transected lesion by regenerated soft tissue
becomes pronounced. After 4 weeks, B type cells in
the deeper layer of the regenerated tissue are
first involved in the production of type 111 and then
in that of type 1 collagens as revealed by the
immunocytochemistry. The present study indicates
that B type cells are a kind of stem cell: they possess
the ability to transform to vasoformative cells involved
in a manner suggestive of vasculogenesis, to phagocytic
A type cells and to the synthetic fibroblasts in the
regeneration of the ACL.
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