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Effects of octreotide on propylotiouracil-induced goiter in rats: a quantitative evaluation

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dc.contributor.authorPawlikowski, M.es
dc.contributor.authorZielinski, K.es
dc.contributor.authorSlowinska-Klencka, D.
dc.contributor.authorKlencki, M.
dc.date.accessioned2011-02-22T10:59:11Z
dc.date.available2011-02-22T10:59:11Z
dc.date.issued1998
dc.description.abstractTo evaluate the possible antigoitrogenic effect of somatostatin, the influence of long-acting somatostatin analog - octreotide - on experimental goiter developed in rats treated with propylthiouracil was examined. Goiter formation was assessed by measurement of the main histological compartments of the thyroid as well as by morphometric analysis of the vascularization and blood supply of the gland. Although treatment with octreotide did not prevent the goiter formation, it clearly reduced blood supply and vascularization of the thyroid and counteracted propylthiouracil- induced increase in the relative volume of follicular epithelium. To conclude, the somatostatin analog - octreotide - is effective in reduction of goiter vascularisation. This finding provides a rationale for the clinical trials of the treatment of hypewascular goiter by somatostatin analogs.es
dc.formatapplication/pdfes
dc.format.extent4es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19089
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectOctreotidees
dc.subjectThyroid glandes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.4 - Patología del sistema linfático, órganos hematopoyéticos, endocrinoses
dc.titleEffects of octreotide on propylotiouracil-induced goiter in rats: a quantitative evaluationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.13, nº 3 (1998)