Publication:
Melatonin promotes self-renewal and nestin expression in neural stem cells from the retina

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dc.contributor.authorGao, Yuhua
dc.contributor.authorMa, Li
dc.contributor.authorBai, Chunyu
dc.contributor.authorZhang, Xiangyang
dc.contributor.authorYang, Wancai
dc.date.accessioned2022-07-01T08:50:29Z
dc.date.available2022-07-01T08:50:29Z
dc.date.issued2019
dc.description.abstractAlthough melatonin has been shown to exhibit a wide variety of biological functions, its effects on promoting self-renewal in retinal stem cells remain unknown. We found that melatonin can significantly increase proliferation and enhance expression of a stem cell marker, nestin, in retinal neural stem cells (NSCs) via melatonin receptor 1 (MT1). The ERK pathway inhibitor SCH772984 and TGF-β pathway inhibitor SB431542 were used to study the melatonin-mediated molecular mechanisms of cell proliferation in NSCs. The results revealed a novel molecular mechanism of melatonin promotion of self-renewal of NSCs in which a chain reaction in the ERK and TGF-β/Smad pathways promotes self-renewal and transcription of nestin. In addition, dual-luciferase assays revealed that Smad4 directly regulated nestin transcription after melatonin treatment in NSCs. These findings revealed novel mechanisms through which the ERK pathway cooperates with the Smad pathway to regulate self-renewal in NSCs to enhance nestin expression.es
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dc.format.extent10es
dc.identifier.citationHistology and Histopathology, Vol.34, nº6, (2019)
dc.identifier.doiDOI: 10.14670/HH-18-065
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/122005
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRetinaes
dc.subjectNeural stem cellses
dc.subjectMelatonines
dc.subjectCell proliferationes
dc.subjectNestin expressiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMelatonin promotes self-renewal and nestin expression in neural stem cells from the retinaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34, nº6 (2019)