Publication: The ultrastructure of alcoholic liver disease: A review and analysis of 100 biopsies
Authors
Grases, Pedro J. ; Millard, Peter R. ; O'D McGee, James.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Liver biopsies from 100 patients with alcoholic
liver disease of various grades of severity were examined
by light and electron microscopy. A comprehensive account
of ultrastructural morphology is presented. The organellar
changes were variable both in nature and intensity. The
most consistent ultrastructural changes, irrespective of
disease severity, were dilatation of endoplasmic reticulum
and fat accumulation. The former is the EM counterpart
of hepatocyte swelling at the light microscope level.
Collagen deposition was detected earlier and more
accurately by electron microscopy. A physical relationship
between Mallory bodies and intermediate filament was also
detected. As is the case with light microscopy, if cellular,
stromal and organellar changes are considered
independently, some may be regarded as typical, but none
as pathognomonic of alcoholic liver disease.
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Citation
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