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Epidemiological surveillance of Neospora caninum in sheep (Ovis aries) and European mouflon (Ovis aries musimon) in southern Spain

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dc.contributor.authorJiménez-Martín, Débora
dc.contributor.authorHuertas-López, Ana
dc.contributor.authorCerón Madrigal, José Joaquín
dc.contributor.authorMartínez-Carrasco Pleite, Carlos
dc.contributor.authorMartínez Subiela, Silvia
dc.contributor.authorPrieto, Paloma
dc.contributor.authorAlmería, Sonia
dc.contributor.authorCano-Terriza, David
dc.contributor.authorGarcía-Bocanegra, Ignacio
dc.contributor.departmentSanidad Animal
dc.contributor.otherFacultad de Veterinaria
dc.date.accessioned2025-12-29T09:06:22Z
dc.date.available2025-12-29T09:06:22Z
dc.date.copyright© 2024 Elsevier Ltd.
dc.date.issued2024-11-02
dc.description.abstractNeospora caninum is a protozoan with a facultative heteroxenous life cycle, with canids as the definitive hosts and other mammals, mainly ruminants, acting as intermediate hosts. This parasite is recognized as one of the major abortifacient pathogens in cattle. Although reproductive disorders have also been reported in other domestic and wild ruminants, epidemiological data on N. caninum in ruminant species other than cattle is still limited. Here, we evaluate the seroprevalence and risk factors associated with N. caninum exposure in sheep (Ovis aries) and European mouflon (Ovis aries musimon) in southern Spain. Serum samples from 390 sheep and 387 free-ranging mouflons were tested for antibodies against N. caninum using in-house time-resolved fluorescence immunoassay based on NcGRA7 as a recombinant antigen. The individual seroprevalence was 26.2 % (95 %CI: 22.0–30.7) in sheep and 5.7 % (95 %CI: 3.8–8.5) in mouflons. At least one seropositive animal was detected in all the 26 sheep farms (100 %) and in eight of the 18 (44.4 %) hunting estates sampled. The presence of dogs on the farm (≥3) and the sheep breed (purebred) were potential risk factors associated with exposure to N. caninum in sheep. Our results indicate a high circulation of N. caninum in sheep farms in southern Spain. Control measures should be implemented to limit the exposure to this protozoan in sheep flocks. Although we have confirmed for the first time the presence of anti- N. caninum antibodies in European mouflon in Spain, and, despite the relatively low seroprevalence found, the impact of this parasite on mouflon populations should be further studied.
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dc.format.extent6
dc.identifier.citationResearch in Veterinary Science 180 (2024) 105444
dc.identifier.doihttps://doi.org/10.1016/j.rvsc.2024.105444
dc.identifier.eissn1532-2661
dc.identifier.issn0034-5288
dc.identifier.urihttp://hdl.handle.net/10201/183129
dc.languageeng
dc.publisherElsevier
dc.relationThis research was partially supported by the CIBER-Consorcio Centro de Investigación Biomédica en Red (CB 2021/13/00083), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea- NextGenerationEU. We would like to thank the Regional Government of Andalusia for providing valuable sheep samples. D. Jiménez-Martín was supported by a FPU grant (FPU22/03649) funded by the Spanish Ministry of Universities. A. Huertas-López was supported by a predoctoral grant from the University of Murcia [grant number R-1207/2017] and by a postdoctoral contract Margarita Salas (University of Murcia) from the Program of Requalification of the Spanish University System (Spanish Ministry of Universities) financed by the European Union — NextGenerationEU [grant number R-1593/2022].
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0034528824003114?via%3Dihub
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAbortion
dc.subjectOvine Mouflon
dc.subjectRuminants
dc.subjectNeosporosis
dc.subjectNeospora caninum
dc.subjectWildlife
dc.subject.odsObjetivo 3: Salud
dc.titleEpidemiological surveillance of Neospora caninum in sheep (Ovis aries) and European mouflon (Ovis aries musimon) in southern Spain
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersión
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