Publication: Prognostic value of CXCR4 expression in
patients with clear cell renal cell carcinoma
Authors
Li, Guorong ; Badin, Grégory ; Zhao, An ; Gentil-Perret, Anne ; Tostain, Jacques ; Péoc’h, Michel ; Gigante, Marc
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Introduction: The expression of CXCR4 is
implicated in the metastatic dissemination of different
cancers. The information on its prognostic value has
been very limited in clear cell renal cell carcinoma
(ccRCC). Our objective was to explore the prognostic
value of CXCR4 in ccRCC. Materials and methods: 104
patients with a ccRCC were studied. There were 69 men
and 35 women with an average age of 64.5 years old
(range: 34-86 years). The CXCR4 expression was
evaluated by immunohistochemistry. The follow-up
varied from 12 to 184 months with a mean of 79.5
months. Kaplan-Meier with a log rank test was
performed to compare overall survival and cancerspecific
survival after surgery. Univariate and
multivariate analyses were performed according to the
Cox regression model. Results: CXCR4 expression was
found in 68/104 (65.4%) of tumor samples. CXCR4
expression was located in the nucleus in 55/68 (80.8%)
cases while cytoplasm or membrane location was found
in 13/68 (19.2%) cases. High expression was found in
25/68 (36.8%) cases. During follow-up, 39 patients died,
of which 26 died of cancer. Kaplan-Meier analysis
revealed that a high expression of CXCR4 was
associated with a reduced overall survival (p=0.017) and
cancer-specific survival (p=0.022). Univariate analysis
indicated that a high expression of CXCR4 was a
significant factor for a poorer overall survival (p=0.020)
and cancer-specific survival (p=0.027). By multivariate
analysis, a high expression of CXCR4 appeared to be an
independent factor of overall survival (p=0.024) and
cancer-specific survival (p=0.028). Conclusion: This
study suggested that a high CXCR4 expression was
correlated with a worse outcome for ccRCC patients.
Citation
Histology and Histopathology, vol. 28, nº 9 (2013)
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