Publication: Autophagy in neurons a review
Authors
Larsen, K.E. ; Sulzer, D.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Macroautophagy is a process of regulated
turnover of cellular constituents that occurs during
development and under conditions of stress such as
starvation. Defects in autophagy have serious
consequences, as they have been linked to
neurodegenerative disease, cancer, and cardiomyopathy.
This process, which exists in all eukaryotic cells, is
tightly controlled, but in extreme cases results in the
death of the cell. While major insights into the molecular
and biochemical pathways involved have come from
genetic studies in yeast, little is known about autophagic
pathways in mammalian cells, particularly in neurons.
Recently, research in neuronal culture models has begun
to identify some characteristics of neuronal
macroautophagy. The results suggest that
macroautophagy in neurons may provide a
neuroprotective mechanism. Here, we review the
defining characteristics of autophagy with special
attention to its role in neurodegenerative disorders, and
recent efforts to delineate the pathway of autophagic
protein degradation in neurons.
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