Publication: Morphometric analysis of brain lesions in rat fetuses prenatally exposed to low-level
lead acetate: correlation with lipid peroxidation
Authors
Villeda-Hernández, J. ; Méndez Armenta, M. ; Barroso-Moguel, R. ; Trejo-Solis, M.C. ; Guevara, J. ; Rios, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effect of prenatal lead acetate exposure
was studied microscopically together with the
concentration of lead and lipid fluorescent products
(LFP) in the brain of rat fetuses. Wistar rats were
intoxicated with a lead solution containing either 160 or
320 ppm of lead acetate solution during 21 days through
drinking water. The control group (ten rats) received
deionized water for the same period. The rats were killed
on gestation day 21 and fetuses were obtained; the
placenta, umbilical cord and parietal cortex (Cx),
striatum (St), thalamus (Th) and cerebellum (Ce) were
collected for measuring tissue lead concentration, LFP as
an index of lipid peroxidation and histopathologic
examination. Lead contents were increased in placenta,
umbilical cord, St, Th and Cx in both lead-exposed
groups. Lead exposure increased (LFP) in placenta and
umbilical cord, St, Th and Ce as compared to the control
group. Histopathological examination showed severe
vascular congestion in placenta, the Cx, St, Th and Ce
with hyperchromatic and shrunken cells. Interstitial
oedema was found in all regions studied of both lead
exposed groups. The morphometric evaluation of the
studied brain regions showed an absolute decrease in
total cell number and increased number of damaged cells and interstitial oedema. Our results show that
morphological changes in rat brain are correlated with
increased lipid peroxidation, and the lead levels of the
umbilical cord, however it is not clear whether oxidative
stress is the cause or the consequence of these
neurotoxic effects of lead.
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