Publication: Mucinous tubular and spindle cell carcinoma with Fuhrman nuclear grade 3, A histological, immunohistochemical, ultrastructural and FISH study
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Date
2008
Authors
Kuroda, Naoto ; Hes, O. ; Michal, Michal ; Nemcova, J. ; Gal, V. ; Yamaguchi, T. ; Kawada, T. ; Imamura, Y. ; Hayashi, Yoshihiro ; Lee, Gang-Hong
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Mucinous tubular and spindle cell carcinoma
(MTSCC) of the kidney generally shows low nuclear
grade. MTSCC with high nuclear grade is relatively rare.
In this article, we report two cases of MTSCC with
Fuhrman grade 3. One case occurred in a 57-year-old
Japanese female and the second case in a 49-year-old
Caucasian female. Histologically, the tumors were
composed of neoplastic cells with cuboidal or columnar
and spindle morphology, and Fuhrman nuclear grade 3.
The myxoid stroma was also observed. This stroma was
positive for Alcian blue stain. Immunohistochemically,
neoplastic cells of both cases were positive for AMACR,
but negative for CD10 and RCC Ma. Ultrastructurally,
tumorous cells of one case contained numerous
mitochondria. In FISH analysis, many neoplastic cells of
both cases demonstrated monosomy of chromosomes 15
and 22 and disomy of chromosomes 7 and 17. One of the
two patients died of respiratory failure due to pleuritis
carcinomatosa 48 months postoperatively. Finally, the
pathologist should recognize that high grade MTSCC
exists despite its rare frequency. FISH analysis may be
helpful in establishing the diagnosis of this entity.
Furthermore, we present the first report of a patient with
MTSCC dying of distant metastasis.
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