Publication: Recovery process of arthritis induced by 6-Sulfanilamidoindazole (6SAI) in rats
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Date
2002
Authors
Ohmachi, Y. ; Fujimura, H. ; Otsuka, E. ; Miyazaki, T. ; Toriumi, W. ; Kitamura, K. ; Doi, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
6-Sulfanilamidoindazole (6SAI) is known to
induce not only an acute arthritis but also serositis and
arteritis which resemble those induced by some
vasodilators in rats. In this study, the recovery process of
ankle lesions was examined histopathologically for up to
12 weeks of recovery period in rats bearing arthritis
induced by administration of 6SAI (500mg/kg) for 2
weeks. At 2 weeks of 6SAI-treatment, e x u d a t ive
s y n ovitis and ex u d a t ive/edematous periarthritis with
m a r ked formation of granulation tissues and periosteal
reactive bone formation were noted in the ankles, but no
remarkable neutrophil infiltration was detected in those
lesions. The ankle swelling induced by 6SAI diminished
by 4 weeks of recovery period, and the elevated plasma
fibrinogen levels were normalized by 2 weeks of
r e c overy period. Although fibrosis and new l y - f o r m e d
periosteal bone were still observed after 2 weeks of
recovery period, no inflammatory lesion was detected at
that point. At 4 or 12 weeks of recovery periods, the
ankles showed an almost normal appearance. These
results indicate that 6SAI-induced arthritis is reve r s i b l e
in nature and does not develop into chronic phase.
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