Publication: Syncytial giant cell component. Review of 55 renal cell carcinomas
Authors
Berzal Cantalejo, F. ; Sabater Marco, V. ; Alonso Hernández, S. ; Jiménez Peña, R. ; Martorell Cebollada, M.A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Different types of multinucleated giant cells
(MGC) have been documented in tumors with
osteoclast-like appearance, with trophoblastic
differentiation or as tumoral malignant giant cells. A
new variety of MGC has been described in renal cell
carcinoma. In order to study the frequency, nature and
significance of this cellular type, we have reviewed our
files.
To assess the presence, nature and significance of
these MGC in renal cell carcinomas and associated
histologic subtype.
To review all malignant renal tumors diagnosed in
the last 5 years in our hospital and to carry out a
morphologic and immunohistochemical study in renal
cell carcinomas with syncytial type MGC.
55 renal cell carcinomas were reviewed. Clear cell
(conventional) renal cell carcinoma was the most
common type encountered (40 cases); two of these cases
showed syncytial type MGC and low grade malignancy.
Microscopically the MGC contained from 5 to 40 nuclei.
Immunohistochemically, mononucleated and
multinucleated cells were positive for cytokeratin CAM
5.2, cytokeratin AE1/AE3 and weakly positive for
vimentin. Histiocytic, muscular, neural markers, beta-
HCG and alpha-fetoprotein were negative.
The presence of syncytial type MGC in renal cell
carcinomas is an exceptional event. Among 55 renal cell
carcinomas we found two cases, both of which were of
clear cell subtype and low grade malignancy. The MGC proved positive for epithelial markers and probably are
the result of mononucleated tumoral cell fusion. We are
unaware of the impact of this MGC in the outcome of
patients; such cells appear in low grade carcinomas and
do not seem to be of dismal prognosis.
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