Publication: Primary B-cell gastric lymphomas of mucosaassociated
lymphoid tissue. Histological
and immunohistochemical study of ten cases
on surgical specimens
Authors
Lavergne, Anne ; Kanavaros, Panagiotis ; Galian, Annie
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Ten cases of gastric mucosa-associated
lymphoid-tissue B-cell lymphoma were studied on
surgical specimens by histology and immunohistochemistry,
with monoclonal and polyclonal antibodies
for B- and T-cells. For the first time, percentage of
centroblast-like cells was appreciated, using their LN1
positivity, by opposition to the negativity of
centrocyte-like cells (LN2 immunoreactivity alone).
Lymphomas were divided into four main groups:
A) centrocyte-like cells; B) centrocyte-like cells and
immunocytoma; C) centrocyte-like cells admixed to
centroblast-like cells; and D) centrocyte-like cells,
immunocytoma and at least 30% of centroblast-like
cells. Group C was divided into 3 subgroups: C1 (rare
centroblast-like cells); C2 (30-50% of centroblast-like
cells); and C3 (predominant centroblast-like cells).
Therefore low grade (A, B, Cl) and high grade
malignancy groups (C2, C3, D) were identified: this
preliminary subdivision could be extended in larger
series and applied to mucosa-associated lymphoidtissue
lymphoma from other sites.
Furthermore, the possible prognostic significance
of this subdivision could be evaluated by correlation
with long term follow up.
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