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Research progress on SIRT1 and sepsis.

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dc.contributor.authorLi, Lincheng
dc.contributor.authorLiu, Mingchuan
dc.contributor.authorCao, Mengyuan
dc.contributor.authorBai, Xiaozhi
dc.date.accessioned2022-10-24T09:29:35Z
dc.date.available2022-10-24T09:29:35Z
dc.date.issued2019
dc.description.abstractSIRT1, a member of the sirtuin family, belongs to the NAD + -dependent class III histone deacetylase. SIRT1 can regulate gene expression by catalyzing non-histone and histone lysine residues deacetylation. SIRT1 also plays important roles in glucose and lipid metabolism, cell aging, tumorigenesis and inflammation. Recent studies indicate that SIRT1 can inhibit the inflammatory responses via regulating several inflammatory signaling pathways. It is closely related to the occurrence and development of sepsis and other inflammatory diseases. Research has been done on relevant signaling pathways of SIRT1 as well as its target genes during inflammation. SIRT1 is a hot spot in uncontrolled inflammatory response research. This article focuses on the role of SIRT1 in inflammation, especially its targets and involved signaling pathways in sepsis, and tries to provide more convincing evidence for the clinical treatment of sepsis and other inflammatory diseases.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationHistology and Histopathology Vol. 34, nº 11 (2019)
dc.identifier.doihttps://doi.org/10.14670/HH-18-146
dc.identifier.urihttp://hdl.handle.net/10201/124824
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSIRT1es
dc.subjectDeacetylasees
dc.subjectSepsises
dc.subjectNF-κBes
dc.subjectMAPKes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleResearch progress on SIRT1 and sepsis.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34,nº11 (2019)