Publication: Myenteric plexus in the gastrointestinal tract of non-obese diabetic mice
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Date
1998
Authors
Spangeus, A. ; El-Salhy, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The myenteric plexus was investigated in the
gastrointestinal tract of pre-diabetic and diabetic nonobese
diabetic (NOD) mice. The plexus was immunostained
by the avidin-biotin complex method, using a
general marker for nerve elements, namely protein geneproduct
9.5. The nerve fibres were quantified by pointcounting
and the number of ganglia and their area were
determined by image analysis. The relative volume
density of the nerve fibres in duodenal muscularis
propria was found to be significantly reduced in of both
pre-diabetic and diabetic NOD mice. There was no
statistical difference between controls and NOD mice
regarding relative volume density of nerve fibres in
antral and colonic muscularis propria. The number of
myenteric ganglialmm baseline was significantly
decreased in the duodenum of diabetic NOD mice, and
showed a non-statistically significant tendency to
decrease in pre-diabetic mice. In the antrum and colon,
there was no difference between the controls and NOD
mice regarding the number of ganglialmm baseline. Nor
was there any significant difference between controls
and NOD mice in the area of myenteric ganglia in either
antrum, duodenum or colon. It is concluded that the
changes in the duodenal myenteric plexus of NOD mice
are prior to the onset of diabetes. It is suggested that the
absence of changes in the antral and colonic myenteric
plexus when using a general marker for neuroelements
does not preclude a possible change in cholinergic,
adrenergic or peptidergic innervation.
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