Publication: Malignant fibrous histiocytoma MFH. A comparison of MFH in man and animals. A critical review
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Date
1999
Authors
Schneider, P. ; Busch, U. ; Meister, H. ; Qasem, Q. ; Wünsch, P.H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This review gives information about
localization and types of MFH in man and animals such
as mouse, rat, cat, dog, opossum, cattle, horse and birds
[e.g. mallard (a wild duck)]. Furthermore, this paper
reports about cell culture dealing with MFH.
The aim of this publication is to show that MFH
originates from a primitive mesenchymal stem cell,
fibroblastoid cell and fibroblasts. Histiocytes are,
according to the literature in a small amount constituents
of MFH and are reactive cells or without any meaning.
In our own studies using rats [strain: Chbb: THOM
(SPF)] the characteristic storiform or cartwheel pattern
of tumour cells were evident. The cells were elongated,
rich in endoplasmic reticulum and possessed no or very
few lysosomes. The cells were predominantly fibroblasts
and fibroblastoid cells. These cells were intermingled
with giant cells. In other species mentioned above, the
MFH showed very similar histological features. Our own
results and findings obtained from the literature support
our concept that the MFH represents a primitive
phenotype or pleomorphic sarcoma which may
differentiate in one or more directions. Histiocytes are
not a neoplastic component.
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