Publication: Promotion of metastasis in nasopharyngeal carcinoma
by Epstein-Barr virus latent membrane protein-1
Authors
Yoshizaki, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Nasopharyngeal carcinoma (NPC) is a
malignant tumor associated with Epstein-Barr virus
(EBV). Latent membrane protein-1 (LMP-1) is an EBVencoded
oncoprotein and is detected in approximately
50-70% of patients with NPC. LMP-1 is thought to play
an essential role in tumorigenesis of NPC. In addition to
its transforming properties, LMP-1 has been suggested
to be associated with promotion of metastasis.
Metastasis is a phenomenon composed of multiple
sequential cascades. Reduction of tumor cell adhesion,
degradation of extracellular matrix, basement
membrane, enhancement of cell motility, and promotion
of neovascularization are thought to be essential steps.
LMP-1 down-regulates expression of E-cadherin,
induces matrix metalloproteinase-9 and urokinase typeplasminogen
activator through activation of NF-?B and
AP-1, and enhances cell motility via ets-1 activation.
LMP-1 also induces vascular endothelial growth factor
through cyclooxygenase-2 activation and interleukin-8
through NF-?B activation. Clinical studies suggested the
association of these factors with metastatic status of
patients with NPC. In this review, the role of LMP-1 in
the metastasis of NPC is discussed.
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