Publication:
Biological interactions between calcium silicate-based endodontic biomaterials and periodontal ligament stem cells: A systematic review of in vitro studies

Simple item page
dc.contributor.advisorSanz, Jose Luís
dc.contributor.authorSanz, Jose Luís
dc.contributor.authorPecci Lloret, María Pilar
dc.contributor.authorPecci Lloret, Miguel Ramón
dc.contributor.authorGuerrero Gironés, Julia
dc.contributor.authorMelo, María
dc.contributor.departmentDermatología, Estomatología, Radiología y Medicina Física
dc.contributor.otherFacultades de la UMU::Facultad de Medicina
dc.date.accessioned2026-02-03T09:57:04Z
dc.date.available2026-02-03T09:57:04Z
dc.date.copyright© 2021 Internacional Endodoncia Diario. Publicado por John Wiley & Hijos Lim
dc.date.created2021-02-15
dc.date.issued2021-08-02
dc.description.abstractBackground: Most recently, the biological interactions, that is cytocompatibility, cell differentiation and mineralization potential, between calcium silicate-based biomaterials and periodontal ligament stem cells (PDLSCs) have been studied at an in vitro level, in order to predict their clinical behaviour during endodontic procedures involving direct contact with periodontal tissues, namely root canal treatment, endodontic surgery and regenerative endodontic treatment. Objective: The aim of the present systematic review was to present a qualitative synthesis of available in vitro studies assessing the biological interaction of PDLSCs and calcium silicate-based biomaterials. Methodology: The present review followed PRISMA 2020 guidelines. An advanced database search was performed in Medline, Scopus, Embase, Web of Science and SciELO on 1 July 2020 and last updated on 22 April 2021. Studies assessing the biological interactions of PDLSCs with calcium silicate-based sealers (CSSs) and/or cements (CSCs) at an in vitro level were considered for inclusion. The evaluation of the ‘biological interaction’ was defined as any assay or test on the cytotoxicity, cytocompatibility, cell plasticity or differentiation potential, and bioactive properties of PDLSCs cultured in CSC or CSS-conditioned media. Quality (risk of bias) was assessed using a modified CONSORT checklist for in vitro studies of dental materials. Results: A total of 20 studies were included for the qualitative synthesis. CSCs and CSSs, as a group of endodontic materials, exhibit adequate cytocompatibility and favour the osteo/ cementogenic differentiation and mineralization potential of PDLSCs, as evidenced from the in vitro studies included in the present systematic review. Discussion: The influence of the compositional differences, inclusion of additives, sample preparation, and varying conditions and manipulations on the biological properties of calcium silicate-based materials remain a subject for future research. Conclusions: Within the limitations of the in vitro nature of the included studies, this work supports the potential use of calcium silicate-based endodontic materials in stem cell therapy and biologically based regenerative endodontic procedures.
dc.formatapplication/msword
dc.identifier.citationSanz JL, Guerrero-Gironés J, Pecci-Lloret MP, Pecci-Lloret MR, Melo M. Biological interactions between calcium silicate-based endodontic biomaterials and periodontal ligament stem cells: A systematic review of in vitro studies. Int Endod J. 2021 Nov;54(11):2025-2043. doi: 10.1111/iej.13600. Epub 2021 Aug 20. PMID: 34338339.
dc.identifier.doihttps://doi.org/10.1111/iej.13600
dc.identifier.eissn1365-2591
dc.identifier.issn0143-2885
dc.identifier.urihttp://hdl.handle.net/10201/198570
dc.languageeng
dc.publisherWILEY
dc.relationEl primero autor recibió fondos de el Español Ministeriode Ciencia, Innovación y Universidades (FPU19/03115).
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCalcium silicate
dc.subjectBioactive materials
dc.subject.odsObjetivo 3: Salud
dc.titleBiological interactions between calcium silicate-based endodontic biomaterials and periodontal ligament stem cells: A systematic review of in vitro studies
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublication0ab0cc54-82a0-416a-9b5a-c69141c6a535
relation.isAuthorOfPublicationde637edb-b207-4075-800c-1e1924c45a29
relation.isAuthorOfPublication361224c9-c577-4e22-a8a4-7c4a75039e3a
relation.isAuthorOfPublication.latestForDiscovery0ab0cc54-82a0-416a-9b5a-c69141c6a535
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Biological interactions between calcium silicate-­ based endodontic biomaterials.pdf
Size:
624.1 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.37 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos