Publication: Connecting cytokines and brain A review of current issues
Authors
Quan, N. ; Herkenham, M.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Cytokines have been a multi-disciplinary
research focus for over 2 decades. To date, there have
been more than 15000 articles published concerning the
relationship between cytokines and the central nervous
system (CNS). Over half of these articles have been
published in the last 5 years. From such vast number of
studies, two major topics emerge as the critical issues: 1)
how do cytokines modulate the functions of the CNS? 2)
what is the role of cytokines in the pathogenesis of
neurological diseases? Thus far, it has been clearly
established that cytokines can alter the functions of the
CNS in specific manners, invoking CNS-controlled
autonomic, neuroendocrine, and behavioral responses.
Induced expression of cytokines has also been found in
the CNS during brain injury and infection, contributing
to the immunological processes at this “immunologically
privileged” site. Furthermore, increasing evidence points
to the potential involvement of cytokines in the
induction and modulation of an array of neurological
diseases ranging from Alzheimer’s disease to chronic
fatigue syndrome. Despite such progress, however,
substantial obstacles remain for both the basic
understanding and the potential clinical exploitation of
how cytokines interact with CNS. In this review, we will
attempt to synopsize the current theories and evidence
regarding the answers to the above-mentioned critical
questions. These issues will be reviewed not only in
isolation, as most of the original reports focused on only
one of the questions, but also in parallel such that interissue
insights may be gained.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.