Publication: Retrospective analysis of 25 immunohistochemical tissue markers for differentiating multilocular cystic renal neoplasm of low malignant potential and multicystic renal cell carcinoma
Authors
Kim, Sung Han ; Park, Boram ; Joo, Jungnam ; Joung, Jae Young ; Seo, Ho Kyung ; Lee, Kang Hyun ; Park, Weon Seo ; Chung, Jinsoo
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-958
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info:eu-repo/semantics/article
Description
Abstract
Multilocular cystic renal neoplasm of low
malignant potential (MCRNLMP) and multicystic renal
cell carcinoma (MCRCC) are morphologically
indistinguishable. MCRNLMP is a tumor composed
entirely of numerous cysts, the septa of which contain
individual or groups of clear cells without expansile
growth. However, unlike MCRCC, neither recurrence
nor metastasis has been reported in MCRNLMP. The
aim of this study was to identify significant differential
pathological characteristics in resected specimens from
patients diagnosed with MCRNLMP (n=13) and
MCRCC (n=17) using immunohistochemistry of 25
tissue markers. Staining interpretation was performed
semi-quantitatively using the H-score (0-300) or
intensity score (0-3), and differences between groups
were evaluated using the Fisher exact and Wilcoxon
rank-sum tests. During a median follow-up of 66.2
months (1-141.9 months), there was only one case of
MCRCC recurrence among all 30 patients, including 19
(63.3%) at stage pT1a, 8 (26.7%) at stage pT1b, and 3
(10.0%) patients at stage pT2. Tumor necrosis rate (0%
vs. 52.9%) and median tumor size (3.2 cm vs. 4.1 cm)
significantly differed between MCRNLMP and MCRCC
samples. Among the 25 tissue markers, only HIF1a,
PDGFRα, SMA, VEGFR1, VEGFR2, VEGFR3, CD10,
CD31, CD34, CK7-tubule, TGAse-2, and Ki-67 showed
significantly different expression between the groups.
These tissue markers with differential expression
between MCRNLMP and MCRCC can provide a clue to
understanding their distinct pathophysiology.
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Citation
Histology and Histopathology, Vol.33, nº6, (2018)
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