Publication: Regional activation of myosin II in cancer cells drives tumor progression via a secretory cross-talk with the immune microenvironment.
Authors
Georgouli, Mirella ; Crosas-Molist, Eva ; Fanshawe, Bruce ; Maiques, Oscar ; Perdrix, Anna ; Pandya, Pahini ; Rodríguez-Hernández, Irene ; Ilieva, Kristina M. ; Cantelli, Gaia ; Karagiannis, Panagiotis ; Mele, Silvia ; Lam, Hoyin ; Josephs, Debra H. ; Matias-Guiu, Xavier ; Marti, Rosa M. ; Nestle, Frank O. ; Orgaz, José L. ; Malanchi, Ilaria ; Fruhwirth, Gilbert O. ; Karagiannis, Sophia N. ; Sanz-Moreno, Victoria ; Herraiz Serrano, Cecilia María
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.cell.2018.12.038
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info:eu-repo/semantics/article
Description
© 2019 The Authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Cell. To access the final edited and published work see https://doi.org/10.1016/j.cell.2018.12.038
Abstract
ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies
revealed that amoeboid melanoma cells with high Myosin II activity are predominant in the invasive fronts of primary tumors in proximity to
CD206+CD163+ tumor-associated macrophages and vessels. Proteomic analysis shows that ROCKMyosin II activity in amoeboid cancer cells controls an immunomodulatory secretome, enabling the recruitment of monocytes and their differentiation into tumor-promoting macrophages. Both amoeboid cancer cells and their associated macrophages support an abnormal vasculature, which ultimately facilitates tumor progression. Mechanistically, amoeboid cancer cells perpetuate their behavior
via ROCK-Myosin II-driven IL-1a secretion and NF-kB activation. Using an array of tumor models, we show that high Myosin II activity in tumor
cells reprograms the innate immune microenvironment to support tumor growth. We describe an unexpected role for Myosin II dynamics in cancer cells controlling myeloid function via secreted factors.
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