Publication: Presence of perivenular elastic fibers in nonalcoholic steatohepatitis Fibrosis Stage III
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Date
2008
Authors
Nakayama, Hirofumi ; Itoh, Hiroyuki ; Kunita, Satoko ; Kuroda, Naoto ; Hiroi, Makoto ; Matsuura, Hideo ; Yasui, Wataru ; Enzan, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Elastic fibers appear in extensive old fibrotic
foci in general. We examined an association between
hepatic fibrosis stage and the presence of perivenular
elastic fibers in nonalcoholic steatohepatitis (NASH). A
total of 48 liver needle biopsy specimens were used,
taken from 48 cases with NASH. Fibrosis Stage (Brunt
E, et al. Am. J. Gastroenterol. 1999) of the cases was as
follows; six Fibrosis Stage I, twenty-two Fibrosis Stage
II, and twenty Fibrosis Stage III. We examined Orcein
stain sections in all of the liver needle biopsy specimens.
In all twenty Fibrosis Stage III cases, perivenular elastic
fiber bundles were observed. In contrast, perivenular
elastic fibers were detected only in one of the six
Fibrosis Stage I and two of the twenty-two Fibrosis
Stage II cases. In liver needle biopsy specimens of
NASH, detection of perivenular elastic fibers is useful in
deciding Fibrosis Stage III.
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