Publication: Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
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Date
1997
Authors
Anglade, P. ; Vyas, S. ; Javoy-Agid, F. ; Michel, P.P. ; Marquez, J. ; Mouatt-Prigent, A. ; Ruberg, M. ; Hirsch, E.C. ; Agid, Y. ; Herrero Ezquerro, María Trinidad
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Parkinson's disease (PD) is a neurodegenerative
disorder characterized by progressive cell
loss confined mostly to dopaminergic neurons of the
substantia nigra. Several factors, including oxidative
stress, and decreased activity of complex 1 mitochondrial
respiratory chain, are involved in the degenerative
process. Yet, the underlying mechanisms leading to
dopaminergic cell loss remain elusive. Morphological
assessrnent for different modes of cell death: apoptosis,
necrosis or autophagic degeneration, can contribute
significantly to the understanding of this neurona1 loss.
Ultrastructural examination revealed characteristics of
apoptosis and autophagic degeneration in melanized
neurons of the substantia nigra in PD patients. The
results suggest that even at the final stage of the disease,
the dopaminergic neurons are undergoing active process
of cell death.
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