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Broccoli byproduct extracts attenuate the expression of UVB-induced proinflammatory cytokines in HaCaT keratinocytes

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dc.archivorevisadoHaCaT keratinocytes
dc.contributor.authorBorja Martínez, María
dc.contributor.authorPedreño García, María Ángeles
dc.contributor.authorSabater Jara, Ana Belén
dc.contributor.departmentBiología Vegetal
dc.date.accessioned2025-05-16T12:04:54Z
dc.date.available2025-05-16T12:04:54Z
dc.date.issued2024-12-02
dc.description© 2024 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in Antioxidants. To access the final edited and published work see https://doi.org/10.3390/antiox13121479
dc.description.abstractBroccoli byproducts are an important source of bioactive compounds, which provide important benefits for human skin due mainly to their antioxidant and anti-inflammatory properties. The primary target of UVB radiation is the basal layer of cells in the epidermis, with keratinocytes being the most abundant cell population in this layer. Given the wide range of side effects caused by exposure to UVB radiation, reducing the amount of UV light that penetrates the skin and strengthening the protective mechanisms of the skin are interesting strategies for the prevention of skin disorders. This work aims to evaluate the protective mechanisms triggered by broccoli by-products extract (BBE) on HaCaT keratinocytes exposed to UVB radiation as well as the study of the regenerative effect of these extracts on the barrier of skin keratinocytes damaged by superficial wounds as a strategy to revalorize this agricultural waste. The results obtained revealed that the BBEs exhibited a high cytoprotective effect on the HaCaT exposed to UVB light, allowing it to effectively reduce the intracellular content of ROS, as well as effectively attenuating the increase in proinflammatory cytokines (IL-1β, IL-6, IL-78, TNF-α) and COX-2 induced by this type of radiation. Furthermore, the BBE could be an excellent regenerative agent for skin wound repair, accelerating the migration capacity of keratinocytes thus contributing to the valorization of this byproduct as a valuable ingredient in cosmetic formulations.
dc.formatapplication/pdfes
dc.format.extent16
dc.identifier.citationAntioxidants, 2024, Vol. 13 (12) : 1479
dc.identifier.doihttps://doi.org/10.3390/ antiox13121479
dc.identifier.issnElectronic: 2076-3921
dc.identifier.urihttp://hdl.handle.net/10201/154786
dc.languageenges
dc.publisherMDPI
dc.relationConsejería de Desarrollo Económico Turismo y Empleo, CARM (RIS3MUR Project), grant number 2I16SA000043.es
dc.relation.publisherversionhttps://www.mdpi.com/2076-3921/13/12/1479
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBroccoli byproducts
dc.subjectProinflammatory cytokines
dc.subjectReactive oxygen species
dc.subjectSkin wound repair
dc.subjectSupercritical fluid extraction
dc.subjectUVB radiation
dc.titleBroccoli byproduct extracts attenuate the expression of UVB-induced proinflammatory cytokines in HaCaT keratinocyteses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication6a60e21b-276a-41c1-9f7e-16b7c933da77
relation.isAuthorOfPublication4c6e7506-0db4-477e-8704-2a1783040719
relation.isAuthorOfPublication.latestForDiscovery6a60e21b-276a-41c1-9f7e-16b7c933da77
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