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Recovery of the pubic symphysis on primiparous young and multiparous senescent mice at postpartum

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dc.contributor.authorConsonni, Silvio Roberto
dc.contributor.authorGiardini Rosa, Renata
dc.contributor.authorCavinato Nascimento, Maria Amália
dc.contributor.authorMendes Vinagre, Cristiane
dc.contributor.authorSzymanski Toledo, Olga Maria
dc.contributor.authorPinto Joazeiro, Paulo
dc.date.accessioned2017-09-07T15:00:58Z
dc.date.available2017-09-07T15:00:58Z
dc.date.issued2012
dc.description.abstractIt has been observed that parturition has a significant effect on female skeletal architecture and that age alters musculoskeletal tissues and their functions. We therefore hypothesized that multiparity affects the recovery of the pubic symphysis in senescent mice at postpartum and the morphology of the interpubic tissues. The pubic symphysis of primiparous young, virgin senescent (VS) and multiparous senescent (MS) Swiss mice was examined by light microscopy, transmission electron microscopy, morphometric analysis and immunohistochemistry. The mouse pubic symphysis was remodeled during the first pregnancy: the cellular phenotype and morphology changed to ensure a structurally safe birth canal, followed by recovery of the interpubic articulation after birth. The morphology of the pubic symphysis in the VS group was maintained in a state similar to that observed in virgin young mice. In contrast, MS mice exhibited an interpubic ligament characterized by extended fibrocyte-like cells, an opened interpubic articulation gap, compacted and thin collagen fibrils and scarce galectin-3-positive cells. Thus, we found that the cellular and extracellular characteristics of the pubic symphysis were altered by multiparity in senescent mice. These particular tissue characteristics of the MS group might be associated with an impaired recovery process at postpartum. Thus, a better understanding of the alterations that occur in the birth canal, including the pubic symphysis, due to multiparity in reproductively aged mice may contribute to our comprehension of the biological mechanisms that modify the skeleton and pelvic ligaments and even play a role in the murine model of pelvic organ prolapsees
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 7 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/54072
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectReproductiones
dc.subjectMultiparityes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleRecovery of the pubic symphysis on primiparous young and multiparous senescent mice at postpartumes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº 7 (2012)