Publication: Analysis of neogenesis in rabbit skeletal muscles after chronic traction
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Date
1994
Authors
Sun, J.S. ; Hou, S.M. ; Liu, T,K. ; Lu, K.S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
After application of a modified Orthofix
mini-extraskeletal fixator, the hind limb of New Zealand
White rabbits was osteotomized and then slowly
lengthened at a rate of 1 mmlday. After a 20 mm gain in
length, the net weight and the length of muscular and
tendinous portions were measured and histological
examination was carried out in triceps surae muscles.
Quantitative analysis showed a significant increase in
the gained length of the muscular portion (28.05% to
30.65%). Histological studies of these lengthened
muscles showed a generalized increase in cellularity
with scanty inflammatory cell infiltration near the
myotendinous junction. The increased cellularity is due
to the presence of muscle precursor cells characterized
by large, oval and pale-stained vesicular nuclei and two
prominent nucleoli. The nuclei of these precursor cells
were larger and more numerous near the myotendinous
junction, and gradually changed into a flattened and
more condensed form at a distance from the junction.
Occasionally, chains of centrally-located nuclei of
primitive myoblasts were also visible. It is concluded
that traction neogenesis of the skeletal muscle during
limb lengthening does exist and occurs mainly near the
myotendinous junction.
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