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Electrical stimulation or MK-801 in the inferior colliculus improve motor deficits in MPTP-treated mice

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dc.contributor.authorMelo Thomas, L
dc.contributor.authorCuenca, L
dc.contributor.authorEstrada, C
dc.contributor.authorGonzalez-Cuello, A
dc.contributor.authorSchwarting, RK
dc.contributor.authorHerrero Ezquerro, María Trinidad
dc.contributor.authorGil Martínez, Ana Luisa
dc.contributor.departmentEnfermería
dc.date.accessioned2024-02-09T09:19:37Z
dc.date.available2024-02-09T09:19:37Z
dc.date.issued2018-01
dc.description.abstractThe inferior colliculus (IC) is an important midbrain relay station for the integration of descending and ascending auditory information. Additionally, the IC has been implicated in processing sensorimotor responses. Glutamatergic and GABAergic manipulations in the IC can improve motor deficits as demonstrated by the animal model of haloperidol-induced catalepsy. However, how the IC influences motor function remains unclear. We investigated the effects of either intracollicular deep brain stimulation (DBS) or microinjection of the glutamatergic antagonist MK-801 or the agonist NMDA in C57BL/6J mice chronically treated with saline or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). After DBS or microinjections, the mice were submitted to rotarod and open field tests, respectively. DBS in the IC was effective to increase the time spent on the rotarod in MPTP-treated mice. After unilateral microinjection of MK-801, but not NMDA, MPTP-treated mice increased the distance travelled in the open field (p < 0.05). In conclusion, intracollicular DBS or MK-801 microinjection can improve motor performance in parkinsonian mice suggesting the IC as a new and non-conventional therapeutic target in motor impairment.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.citationNeuroToxicology 65 (2018) 38–43
dc.identifier.doihttps://doi.org/10.1016/j.neuro.2018.01.004
dc.identifier.issn0161-813X
dc.identifier.urihttp://hdl.handle.net/10201/139066
dc.languageenges
dc.publisherElsevier. Science Directes
dc.relationSupported by FIS PI13 01293 & Fundación Séneca 19540/PI/14.es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0161813X18300238?via%3Dihub
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDeep brain stimulationes
dc.subjectParkinson’s diseasees
dc.subjectMPTPes
dc.subjectMPTPes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::611 - Anatomíaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nerviosoes
dc.titleElectrical stimulation or MK-801 in the inferior colliculus improve motor deficits in MPTP-treated micees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication9bbe7af5-429b-4029-b621-0399a6838322
relation.isAuthorOfPublication848746a7-05ac-4d08-82cb-e6a80680c24f
relation.isAuthorOfPublication.latestForDiscovery9bbe7af5-429b-4029-b621-0399a6838322
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