Publication:
Morphologic and molecular diagnostic criteria of malignancies in biliary strictures

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dc.contributor.authorAlbertini, Elisa
dc.contributor.authorMiranda, Lucia
dc.contributor.authorMaloberti, Thais
dc.contributor.authorBiase, Dario de
dc.contributor.authorVasuri, Francesco
dc.date.accessioned2025-03-18T08:51:08Z
dc.date.available2025-03-18T08:51:08Z
dc.date.issued2025
dc.description.abstractThe differential diagnosis of benign and malignant biliary strictures is not always feasible and still represents a major diagnostic challenge, mainly due to the scarcity of the tissue retrieved for proper cytological or histopathological diagnosis. The present review focuses on morphological criteria in the diagnosis of biliary strictures, in the course of primary sclerosing cholangitis and other pathologies, starting from the limits of the cytological and histological evaluation, as well as the ancillary methodologies currently available in Pathology laboratories The current guidelines suggest fluorescence in situ hybridization for the analysis of chromosomes 3, 7, and 17 polysomies and deletion of the 9p21 locus; however, other more promising techniques are on the horizon for both patient care and research purposes, such as Next-Generation Sequencing, able to analyze multiple genes simultaneously in a cost-effective fashion. Lastly, the most recent approaches proposed in the literature for the differential diagnosis of biliary stricture are described, such as circulating tumor DNA, miRNAs, and DNA methylation, among others.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and Histopathology Vol. 40, nº04 (2025)
dc.identifier.doihttps://doi.org/10.14670/HH-18-811
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/151822
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAncillary techniqueses
dc.subjectBiliary strictureses
dc.subjectCholangiocellular carcinomaes
dc.subjectFISHes
dc.subjectHistopathologyes
dc.subjectNext generation sequencinges
dc.subjectPrimary sclerosing cholangitises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMorphologic and molecular diagnostic criteria of malignancies in biliary strictureses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nº4 (2025)