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Evaluation of the presence of gingivitis as confounding factor in assessing inflammatory status in serum and saliva of dogs with diabetes mellitus

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dc.contributor.authorFranco-Martínez, Lorena
dc.contributor.authorMuñoz Prieto, Alberto
dc.contributor.authorBusato, Francesca
dc.contributor.authorKarveliene, Birute
dc.contributor.authorStadaliene, Inga
dc.contributor.authorCerón, José J.
dc.contributor.authorCarrillo, Juana D.
dc.contributor.authorGarcía Martínez, Juan Diego
dc.contributor.authorDabrowski, Roman
dc.contributor.authorPardo Marín, Luis
dc.contributor.authorMartínez Subiela, Silvia
dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2025-01-16T08:17:34Z
dc.date.available2025-01-16T08:17:34Z
dc.date.issued2024-03-23
dc.description© The Author(s) 2024. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in BMC Veterinary Research. To access the final edited and published work see https://doi.org/10.1186/s12917-024-03962-8es
dc.description.abstractThe aim of this study was to evaluate the changes in the serum and salivary inflammatory markers induced by Diabetes mellitus (DM) in dogs and to assess the possible confounding effect of gingivitis. A panel of 13 cytokines was measured in the serum and saliva of dogs diagnosed with DM and compared with healthy dogs without gingivitis (control group 1; CG1) and dogs with gingivitis but otherwise healthy (control group 2; CG2). The results of the present study showed statistically significantly higher levels of IL-8, KC-like and MCP1 in the serum of dogs with DM compared to CG1 dogs. In the case of saliva, the DM group presented statistically higher GM-CSF, IL6, IL15, and MCP1 levels compared to CG1, and lower KC-like chemokine compared to CG2. Finally, gingivitis produced changes in saliva, with salivary levels of GM-CSF, IL-6, IL-7, IL-15, IP-10, KC-like, IL-10, IL-18, MCP1, TNFα being statistically significantly higher in the saliva of CG2 dogs compared to CG1. The results of the present study indicate that dogs with DM have altered cytokine levels in serum and saliva compared to healthy dogs. In addition, this study highlights the importance of taking oral health into account when determining cytokines in dogs, as gingivitis can significantly alter their concentrations.es
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dc.identifier.citationBMC Veterinary Research, 2024, Vol. 20 : 116
dc.identifier.doihttps://doi.org/10.1186/s12917-024-03962-8
dc.identifier.issnElectronic: 1746-6148
dc.identifier.urihttp://hdl.handle.net/10201/148547
dc.languageenges
dc.publisherBioMed Centrales
dc.relationThis work was supported by the Seneca Foundation-Agency of Science and Technology of the Region of Murcia through the Subprogram to the Scientific Leadership and the Transition to the Independent Investigation (20649/JLI/18). LFM and AMP are funded by the University of Murcia through a post-doctoral grant (Margarita Salas) within the mark of “Ayudas en el marco del Programa para la Recualificación del Sistema Universitario Español” through the European Union Next Generation funds.es
dc.relation.publisherversionhttps://bmcvetres.biomedcentral.com/articles/10.1186/s12917-024-03962-8es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCaninees
dc.subjectDiabetes mellituses
dc.subjectGingivitises
dc.subjectInterleukinses
dc.subjectSalivaes
dc.titleEvaluation of the presence of gingivitis as confounding factor in assessing inflammatory status in serum and saliva of dogs with diabetes mellituses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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