Publication: Alterations induced by cyclosporine A in myocardial fibers and extracellular matrix in rat
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Date
2002
Authors
Rezzani, R. ; Angoscini, P. ; Rodella, L.F. ; Bianchi, R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cyclosporine A (CsA) is the first choice
immunosuppressant universally used in allotransplantation.
However, it has been demonstrated that
this drug produces unwanted side effects in several
organs and in particular in the kidney and in the heart.
While the cardiac toxicity, due to alteration of
myocardial prostanoid has been reported, no data are
available about the effects of CsA on myocardial
cytoarchitecture. We studied the CsA induced alterations
of the myocardial structure and of the extracellular
matrix components (ECM). To test the ECM enzymatic
changes we studied a family of enzymes (matrix
metalloproteinase-MMP), responsible for the
degradation of extracellular matrix components. In
particular we investigated MMP1, MMP2 and MMP9.
The study was carried out on two groups of Wistar
rats. The group I animals served as a control and were
injected subcutaneously daily with castor oil for 21 days.
Group II: animals were subcutaneously injected daily
with CsA (dose: 15 mg/Kg in castor oil) for 21 days. The
group I animals (control) had normal heart architecture
and low levels of MMP1, MMP2 and MMP9. The group
II animals showed degenerative changes with
myocardial fibrosis, low levels of MMP1 and MMP9 but
a clear increase in MMP2.
We suggest that the myocardial fibrosis was a
consequence of the cardiotoxic effect of CsA
determining the alteration of the balance between
synthesis and degradation of ECM. The increase in
MMP2 suggests that this enzyme could play a protective
role during myocardial damage and represent a
compensatory mechanism for the excessive
accumulation of collagen.
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